Jean-Pierre Julien Selected Research

Superoxide Dismutase-1

1/2020	Mitigation of ALS Pathology by Neuron-Specific Inhibition of Nuclear Factor Kappa B Signaling.
1/2018	Overexpressed wild-type superoxide dismutase 1 exhibits amyotrophic lateral sclerosis-related misfolded conformation in induced pluripotent stem cell-derived spinal motor neurons.
11/2016	From animal models to human disease: a genetic approach for personalized medicine in ALS.
1/2015	Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis.
3/2014	Adeno-associated virus-mediated delivery of a recombinant single-chain antibody against misfolded superoxide dismutase for treatment of amyotrophic lateral sclerosis.
10/2013	Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1.
4/2012	Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS.
12/2010	Neuronal over-expression of chromogranin A accelerates disease onset in a mouse model of ALS.
11/2010	Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.
10/2010	Induction of protective immunity by vaccination with wild-type apo superoxide dismutase 1 in mutant SOD1 transgenic mice.

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Jean-Pierre Julien Research Topics

Disease

43	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2020 - 08/2002
12	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 08/2002
6	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2012 - 11/2002
5	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2021 - 09/2011
4	TDP-43 Proteinopathies 01/2021 - 01/2017
4	Disease Progression 01/2018 - 08/2002
3	Proteostasis Deficiencies 11/2020 - 01/2017
3	Frontotemporal Dementia (Semantic Dementia) 01/2019 - 09/2011
3	Inflammation (Inflammations) 12/2015 - 08/2002
3	Breast Neoplasms (Breast Cancer) 05/2009 - 10/2002
2	Brain Injuries (Brain Injury) 01/2020 - 08/2002
2	Neuroinflammatory Diseases 01/2017 - 09/2011
2	Alzheimer Disease (Alzheimer's Disease) 04/2014 - 08/2002
2	Noninfiltrating Intraductal Carcinoma (DCIS) 11/2013 - 07/2006
2	Giant Axonal Neuropathy 05/2013 - 08/2011
2	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 03/2012 - 12/2007
2	Paralysis (Palsy) 09/2011 - 08/2006
2	Type 2E Charcot-Marie-Tooth disease 07/2010 - 12/2007
2	Neoplasms (Cancer) 05/2009 - 07/2006
2	Juvenile Amyotrophic Lateral Sclerosis 2 09/2008 - 01/2005
1	Schizophrenia (Dementia Praecox) 01/2018
1	Sarcoma (Soft Tissue Sarcoma) 11/2016
1	Hypersensitivity (Allergy) 12/2015
1	Pain (Aches) 12/2015
1	Wounds and Injuries (Trauma) 12/2015
1	Neuromuscular Diseases (Neuromuscular Disease) 01/2015
1	Cognitive Dysfunction 04/2014
1	Nervous System Diseases (Neurological Disorders) 05/2013
1	Dementia (Dementias) 12/2012
1	Gliosis 09/2011
1	Muscular Atrophy (Muscle Atrophy) 10/2008
1	Sciatic Neuropathy (Lesion of Sciatic Nerve) 09/2008
1	Type 2F Charcot-Marie-Tooth disease 12/2007
1	Glioma (Gliomas) 09/2007
1	Multiple Sclerosis 04/2007
1	Late Onset Disorders 02/2007
1	Central Nervous System Diseases (CNS Diseases) 09/2006
1	Amyloid Plaque 02/2006
1	Retinoblastoma (Glioblastoma, Retinal) 03/2003

Drug/Important Bio-Agent (IBA)

19	Superoxide Dismutase-1IBA 01/2020 - 11/2002
13	Superoxide DismutaseIBA 01/2020 - 08/2002
13	Proteins (Proteins, Gene)FDA Link 06/2012 - 03/2003
10	PeripherinsIBA 06/2012 - 08/2002
9	DNA-Binding Proteins (DNA Binding Protein)IBA 11/2020 - 09/2011
3	Neurofilament ProteinsIBA 01/2021 - 03/2012
3	withaferin AIBA 01/2021 - 01/2015
3	Chromogranin BIBA 11/2016 - 12/2009
3	Pharmaceutical PreparationsIBA 01/2012 - 11/2006
3	ChromograninsIBA 12/2010 - 01/2006
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 01/2019
2	CytokinesIBA 12/2015 - 11/2006
2	Ganciclovir (Cytovene)FDA LinkGeneric 09/2008 - 09/2007
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2007 - 11/2006
2	Minocycline (Cyclops)FDA LinkGeneric 08/2006 - 08/2002
2	Dihydrotachysterol (AT 10)IBA 07/2006 - 10/2002
1	NF-kappa B (NF-kB)IBA 01/2021
1	Proteasome Endopeptidase Complex (Proteasome)IBA 11/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	Plant ExtractsIBA 11/2018
1	Pimozide (Orap)FDA Link 01/2018
1	N-Methylaspartate (NMDA)IBA 01/2018
1	Antipsychotic Agents (Antipsychotics)IBA 11/2017
1	AshwagandhaIBA 01/2017
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2016
1	Freund's AdjuvantIBA 12/2015
1	AntigensIBA 12/2015
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 12/2015
1	Ubiquitinated ProteinsIBA 01/2015
1	LipopolysaccharidesIBA 01/2015
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 05/2013
1	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2012
1	Glial Fibrillary Acidic ProteinIBA 09/2011
1	LuciferasesIBA 09/2011
1	ZincIBA 11/2010
1	CopperIBA 11/2010
1	Doxycycline (Periostat)FDA LinkGeneric 07/2010
1	Macrophage Colony-Stimulating FactorIBA 12/2009
1	Epirubicin (Ellence)FDA LinkGeneric 05/2009
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 05/2009
1	Fluorouracil (Carac)FDA LinkGeneric 05/2009
1	antineoplaston A10 (A 10)IBA 10/2008
1	Messenger RNA (mRNA)IBA 09/2008
1	neurofilament protein LIBA 12/2007
1	Small Heat-Shock ProteinsIBA 12/2007
1	Green Fluorescent ProteinsIBA 09/2007
1	Glatiramer Acetate (Copaxone)FDA Link 04/2007
1	Therapeutic UsesIBA 02/2007
1	alpha-internexinIBA 09/2006
1	Thymidine KinaseIBA 02/2006
1	Cyclin-Dependent Kinase 5IBA 09/2003
1	Retinoblastoma ProteinIBA 03/2003

Therapy/Procedure

5	Therapeutics 01/2021 - 10/2002
2	Radiotherapy 11/2013 - 07/2006
1	Oral Administration 01/2021
1	Intraventricular Infusions 01/2020
1	Denervation 01/2015
1	Adjuvant Radiotherapy 11/2013
1	Nerve Crush 12/2012
1	Drug Therapy (Chemotherapy) 05/2009
1	Injections 02/2004